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Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo

Fellner, Stephan and Bauer, Björn and Miller, David S. and Schaffrick, Martina and Fankhänel, Martina and Spruß, Thilo and Bernhardt, Günther and Graeff, Claudia and Färber, Lothar and Gschaidmeier, Harald and Buschauer, Armin and Fricker, Gert (2002) Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. The Journal of Clinical Investigation 110 (9), pp. 1309-1318.

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Other URL: http://www.jci.org/cgi/content/full/110/9/1309


Abstract

Paclitaxel concentrations in the brain are very low after intravenous injection. Since paclitaxel is excluded from some tumors by p-glycoprotein (p-gp), the same mechanism may prevent entry into the brain. In vitro, paclitaxel transport was examined in capillaries from rat brains by confocal microscopy using BODIPY Fl-paclitaxel. Western blots and immunostaining demonstrated apical expression of ...

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Item Type:Article
Date:2002
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
10.1172/JCI15451DOI
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:21 Feb 2008 10:33
Last Modified:13 Mar 2014 19:36
Item ID:3399
Owner Only: item control page

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