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Agonist internalization by cloned Y1 neuropeptide Y (NPY) receptor in Chinese hamster ovary cells shows strong preference for NPY, endosome-linked entry and fast receptor recycling.

Parker, S.L. and Parker, M. S. and Lundell, I. and Balasubramaniam, A. and Buschauer, Armin and Kane, J. K. and Yalcin, A. and Berglund, M. M. (2002) Agonist internalization by cloned Y1 neuropeptide Y (NPY) receptor in Chinese hamster ovary cells shows strong preference for NPY, endosome-linked entry and fast receptor recycling. Regulatory Peptides 107 (1-3), pp. 49-62.

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Abstract

In Chinese hamster ovary (CHO) cells expressing the cloned guinea-pig Y1 receptor, the saturable, receptor-linked internalization of NPY (NPY)-related peptides showed the rank order of human/rat neuropeptide Y (hNPY)>pig/rat peptide YY (pPYY)>=(Pro34)human PYY>(Leu31,Pro34)hNPY>(Leu31,Pro34)hPYYmuch greater-thanBVD-11 (a selective Y1 antagonist). All agonists accessed similar numbers of Y1 sites ...

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Item Type:Article
Date:2002
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
10.1016/S0167-0115(02)00094-0DOI
Keywords:Y1 antagonist; Y1 agonist; Chaotropic agent; Transferrin; Endosome; Lysosome
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:21 Feb 2008 10:38
Last Modified:05 Aug 2009 13:42
Item ID:3400
Owner Only: item control page
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