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Structure-Activity Relationships of Neuropeptide Y Y_1 Receptor Antagonists Related to BIBP 3226,

Aiglstorfer, Iris and Hendrich, Ingo and Moser, Christiane and Bernhardt, Günther and Dove, Stefan and Buschauer, Armin (2000) Structure-Activity Relationships of Neuropeptide Y Y_1 Receptor Antagonists Related to BIBP 3226,. Bioorganic & Medicinal Chemistry Letters 10 (14), pp. 1597-1600.

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Other URL: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF9-40TY716-X&_user=616165&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000032338&_version=1&_urlVersion=0&_userid=616165&md5=157b239cf8a5eb9b364d7cdfc567eed1


Abstract

Analogues of BIBP 3226, (R)-Nα-diphenylacetyl-N-(4-hydroxybenzyl)argininamide, were synthesized and investigated for Y1 antagonism (Ca2+-assay, HEL cells) and binding on Y1, Y2 and Y5 receptors. Replacing the benzylamino by a tetrahydrobenzazepinyl group preserves most of the Y1 activity. Combination with a NG-phenylpropyl arginine and a Nα-p-biphenylylacetyl moiety shifted the NPY receptor ...

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Item Type:Article
Date:2000
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
10.1016/S0960-894X(00)00292-4DOI
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:22 Feb 2008 07:51
Last Modified:05 Aug 2009 13:42
Item ID:3407
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