Schuster, Andreas and Bernhardt, Günther and Eibler, Ernst and Buschauer, Armin and Hesselink, Willy (1998) Chiral separation of 3-phenyl-3-(2-pyridyl)propylamines, and analogous guanidines and guanidine-N-carboxylic acid esters with HPLC and CZE. Journal of Chromatography A 793 (1), pp. 77-90.
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We present a high-performance liquid chromatography (HPLC) and a capillary zone electrophoresis (CZE) method for the chiral separation of 3-phenyl-3-(2-pyridyl)propylamines, -guanidines and -guanidine-N-carboxylic acid esters. The N-alkoxycarbonylguanidines were resolved into enantiomers on a Chiralpak AD column with resolutions ≥2.0. The separation of chloro-substituted 3-phenyl-3-(2-pyridyl)propylamines was performed on a Cyclobond I column and a RP18 column, dynamically coated with β-cyclodextrin (CD). The analytical resolution of all compounds was achieved by CZE using α-, β- or γ-CD as chiral selectors. After determination of the best suited CD, buffer pH, CD concentration and capillary temperature were optimized for each individual analyte, resulting in resolutions ≥1.2.
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)|
|Keywords:||Phenylpyridylpropylamines; Arpromidine; Guanidines; Histamine agonists|
|Subjects:||500 Science > 570 Life sciences|
600 Technology > 610 Medical sciences Medicine
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Owner:||Prof. Armin Buschauer|
|Deposited On:||22 Feb 2008 13:26|
|Last Modified:||05 Aug 2009 13:42|