Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma

URN zum Zitieren dieses Dokuments:

urn:nbn:de:bvb:355-epub-343653 Copy

DOI zum Zitieren dieses Dokuments:

10.5283/epub.34365 Copy

Dierlamm, J. ; Murga Penas, E. M. ; Bentink, Stefan ; Wessendorf, S. ; Berger, H. ; Hummel, M. ; Klapper, W. ; Lenze, D. ; Rosenwald, A. ; Haralambieva, E. ; Ott, G. ; Cogliatti, S. B. ; Möller, Peter ; Schwaenen, C. ; Stein, H. ; Löffler, M. ; Spang, Rainer ; Trumper, L. ; Siebert, Reiner

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PDF - Veröffentlichte Version (184kB)

Veröffentlichungsdatum dieses Volltextes: 17 Aug 2016 13:52

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Details

Dokumentenart:	Artikel
Open Access Art:	Gold (mit APC - nicht UR)
Titel eines Journals oder einer Zeitschrift:	Haematologica
Verlag:	Ferrata Storti Foundation
Band:	93
Nummer des Zeitschriftenheftes oder des Kapitels:	5
Seitenbereich:	S. 688-696
Datum:	Mai 2008
Institutionen:	Medizin > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) Informatik und Data Science > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identifikationsnummer:	Wert Typ 18367485 PubMed-ID 10.3324/haematol.12057 DOI
Dewey-Dezimal-Klassifikation:	600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
Status:	Veröffentlicht
Begutachtet:	Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:	Zum Teil
Dokumenten-ID:	34365

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Zusammenfassung

BACKGROUND: The aim of this study was to determine the impact of a gain of the MALT1 gene on gene expression and clinical parameters in diffuse large B-cell lymphoma. DESIGN AND METHODS: We analyzed 116 cases of diffuse large B-cell lymphoma by fluorescence in situ hybridization, array-based comparative genomic hybridization, and transcriptional profiling. RESULTS: A gain of 18q21 including MALT1 ...

Zusammenfassung

BACKGROUND:
The aim of this study was to determine the impact of a gain of the MALT1 gene on gene expression and clinical parameters in diffuse large B-cell lymphoma.
DESIGN AND METHODS:
We analyzed 116 cases of diffuse large B-cell lymphoma by fluorescence in situ hybridization, array-based comparative genomic hybridization, and transcriptional profiling.
RESULTS:
A gain of 18q21 including MALT1 was detected in 44 cases (38%) and was accompanied by a gain of BCL2 in 43 cases. All cases with a 18q21/MALT1 gain showed BCL2 protein whereas 79% in the group without a 18q21/MALT1 gain did so (p<0.001). Cases with 18q21/MALT1 gain more frequently showed an activated B-cell-like (ABC) gene expression signature (65%) than a germinal center B-cell-like (GCB) one (23%) (p<0.001). Ninety-eight genes including MALT1, BCL2, and some selected nuclear factor-kappaB target genes were differentially expressed between the two genetic groups of diffuse large B-cell lymphoma. By global testing of each chromosome, we identified 33 genes, all located on chromosome 18q, which were differentially expressed between the two genetic groups independently of the ABC/GCB status. In multivariate analysis, the 18q21/MALT1 status represented an independent negative prognostic factor for overall survival (p=0.03).
CONCLUSIONS:
In diffuse large B-cell lymphoma, gain of 18q21 including MALT1 is significantly associated with differential expression of genes located on 18q, the ABC gene expression subtype, increased BCL2 gene and protein expression and might indicate an unfavorable prognosis.

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