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Side-chain modified analogues of histaprodifen: Asymmetric synthesis and histamine H₁-receptor activity

Patil, Rameshwar and Elz, Sigurd and Reiser, Oliver (2006) Side-chain modified analogues of histaprodifen: Asymmetric synthesis and histamine H₁-receptor activity. Bioorg. Med. Chem. Lett. 16 (3), pp. 672-676.

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Other URL: http://dx.doi.org/10.1016/j.bmcl.2005.10.030


Abstract

New analogues of histaprodifen with polar side chains have been stereoselectively synthesized and evaluated as histamine H₁-receptor agonists. As a key transformation the asymmetric aminohydroxylation has been used, which was successfully realized for the first time on an imidazolyl derivative. While all chiral analogues proved to be weak H₁-receptor antagonists, an achiral keto derivative of ...

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Item Type:Article
Date:1 February 2006
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
Identification Number:
ValueType
10.1016/j.bmcl.2005.10.030DOI
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Helge Knüttel (ADMIN)
Deposited On:05 Sep 2006
Last Modified:05 Aug 2009 13:22
Item ID:359
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