Deutsch
Gheorghe, Alexandru and Schulte, Michael and Reiser, Oliver (2006) Synthesis of Functionalized Pyrrolidin-2-ones and
(S)-Vigabatrin from Pyrrole. The Journal of Organic Chemistry 71 (5), pp. 2173-2176.
Full text not available from this repository.
Other URL: http://dx.doi.org/10.1021/jo0524472
Abstract
Starting from pyrrole, the novel 3,4-didehydropyrohomoglutamate 8 or (ent)-8 can be efficiently synthesized in up to 91% ee, which can be utilized as a versatile building block toward functionalized pyrrolidin-2-ones. Moreover, (ent)-8 can be readily converted to (S)-Vigabatrin, being an irreversible inhibitor for GABA-T, which is used as adjunctive therapy in patients that suffer from epilepsy.
| Item Type: | Article | ||||
|---|---|---|---|---|---|
| Institutions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser | ||||
| Identification Number: |
| ||||
| Subjects: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Unknown | ||||
| Owner: | Helge Knüttel (ADMIN) | ||||
| Deposited On: | 06 Sep 2006 | ||||
| Last Modified: | 05 Aug 2009 15:22 | ||||
| Item ID: | 368 |
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