Gheorghe, Alexandru and Schulte, Michael and Reiser, Oliver
Synthesis of Functionalized Pyrrolidin-2-ones and
(S)-Vigabatrin from Pyrrole. The Journal of Organic Chemistry 71 (5), pp. 2173-2176.
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Other URL: http://dx.doi.org/10.1021/jo0524472
Starting from pyrrole, the novel 3,4-didehydropyrohomoglutamate 8 or (ent)-8 can be efficiently synthesized in up to 91% ee, which can be utilized as a versatile building block toward functionalized pyrrolidin-2-ones. Moreover, (ent)-8 can be readily converted to (S)-Vigabatrin, being an irreversible inhibitor for GABA-T, which is used as adjunctive therapy in patients that suffer from epilepsy.
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|Date:||3 March 2006|
|Institutions:||Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser|
|Dewey Decimal Classification:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited on:||06 Sep 2006|
|Last modified:||05 Aug 2009 13:22|