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Synthesis of substituted pyrimidine hydrazine acids (PHA) and their use in peptide recognition

Miltschitzky, Stefan and Michlova, Veronika and Stadlbauer, Stefan and König, Burkhard (2006) Synthesis of substituted pyrimidine hydrazine acids (PHA) and their use in peptide recognition. Heterocycles 67 (1), pp. 135-160.

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Abstract

Substituted pyrimidine-hydrazine-acids (PHA) were prepared from orotic acid in five synthetic steps and high yields. Their geometry of hydrogen bond acceptor and donor sites make them suitable for the molecular recognition of peptide β-sheets. In non-protic solvents the PHA unit emits at around 420 nm after irradiation at 281 nm. The emission intensity decreases upon peptide binding and signals ...

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Item Type:Article
Date:1 January 2006
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Regina Hoheisel
Deposited On:05 Jul 2006
Last Modified:10 Mar 2011 11:42
Item ID:40
Owner Only: item control page
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