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Screening of Metal Complex – Amino Acid Side Chain Interactions by Potentiometric Titration

Kruppa, Michael and Frank, Daniel and Leffler-Schuster, Helga and König, Burkhard (2006) Screening of Metal Complex – Amino Acid Side Chain Interactions by Potentiometric Titration. Inorganica Chimica Acta 359 (4), pp. 1159-1168.

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Abstract

Reversible coordination of amino acid side chains to metal complexes is widely used in protein purification (IMAC technique), but available data on affinity and selectivity of such binding processes are limited. We use potentiometric titration of a series of metal complexes with vacant coordination sites in the presence of molecules resembling amino acid side chain functionalities to screen for ...

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Item Type:Article
Date:1 March 2006
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1016/j.ica.2005.12.008DOI
Keywords:Potentiometric titration; Coordinative binding; IDA; NTA; Cyclen; Binding constant
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Regina Hoheisel
Deposited On:05 Jul 2006
Last Modified:13 Mar 2014 09:38
Item ID:45
Owner Only: item control page
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