Deutsch
Igel, Patrick and Schnell, David and Bernhardt, Günther and Seifert, Roland and Buschauer, Armin (2009) Tritium-labeled N1-[3-(1H-imidazol-4-yl)propyl]-N2-propionylguanidine ([3H]UR-PI294), a high affinity histamine H3 and H4 receptor radioligand. ChemMedChem 4 (2), pp. 225-231.
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Other URL: http://www3.interscience.wiley.com/cgi-bin/fulltext/121579667/PDFSTART, http://www.ncbi.nlm.nih.gov/pubmed/19101971?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
Abstract
This study reports the synthesis and pharmacological characterization of tritium-labeled N1-[3-(1H-imidazol-4-yl)propyl]-N2-propionyl¬guanidine ([3H]UR-PI294), a novel readily accessible radioligand for the human histamine H3 receptor (hH3R) and H4 receptor (hH4R). The radioligand displayed high affinity for both histamine receptor subtypes (KD (hH3R) = 1.1 nM, KD (hH4R) = 5.1 nM) and was shown to serve as a valuable pharmacological tool for the determination of hH3R and hH4R affinities.
| Item Type: | Article | ||||||
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| Additional information (public): | Online publiziert am 19. Dezember 2008 | ||||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert) | ||||||
| Projects: | GRK 760, Graduiertenkolleg Medizinische Chemie | ||||||
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| Keywords: | histamine H3 receptor; histamine H4 receptor; radiolabeled H3 receptor ligand; radiolabeled H4 receptor ligand; acylguanidine; imidazolylpropylguanidine | ||||||
| Subjects: | 500 Science > 570 Life sciences 500 Science > 540 Chemistry & allied sciences | ||||||
| Status: | Published | ||||||
| Refereed: | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg: | Yes | ||||||
| Owner: | Prof. Armin Buschauer | ||||||
| Deposited On: | 29 Oct 2008 22:04 | ||||||
| Last Modified: | 05 Aug 2009 15:48 | ||||||
| Item ID: | 4682 |
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