Startseite UB

[(2-Phenylindol-3-yl)methylene]propanedinitriles inhibit the growth of breast cancer cells by cell cycle arrest in G(2)/M phase and apoptosis

Pojarová, Michaela and Kaufmann, Doris and Gastpar, Robert and Nishino, Tsuyuki and Reszka, Przemyslaw and Bednarski, Patrick J. and Angerer, Erwin von (2007) [(2-Phenylindol-3-yl)methylene]propanedinitriles inhibit the growth of breast cancer cells by cell cycle arrest in G(2)/M phase and apoptosis. Bioorganic & medicinal chemistry 15 (23), pp. 7368-7379.

Full text not available from this repository.

at PubMed

at publisher (via DOI)


Abstract

Cell cycle arrest of malignant cells is an important option for cancer treatment. In this study, we modified the structure of antimitotic 2-phenylindole-3-carbaldehydes by condensation with malononitrile. The resulting methylene propanedinitriles inhibited the growth of MDA-MB 231 and MCF-7 breast cancer cells with IC(50) values below 100 nM. Though they exhibited similar structure-activity ...

plus


Export bibliographical data

Item Type:Article
Date:2007
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
17889547PubMed ID
10.1016/j.bmc.2007.07.046DOI
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/administration & dosageMESH
Apoptosis/drug effectsMESH
Caspases/antagonists & inhibitorsMESH
Cell Cycle/drug effectsMESH
Cell Division/drug effectsMESH
Cell Line, TumorMESH
Cell Proliferation/drug effectsMESH
Disease Models, AnimalMESH
Dose-Response Relationship, DrugMESH
Drug Screening Assays, AntitumorMESH
G2 Phase/drug effectsMESH
HumansMESH
Indoles/chemistryMESH
Mammary Neoplasms, Experimental/drug therapyMESH
MiceMESH
Molecular StructureMESH
Nitriles/chemistryMESH
StereoisomerismMESH
Structure-Activity RelationshipMESH
Tubulin/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:12 Dec 2008 16:27
Last Modified:05 Aug 2009 13:48
Item ID:4710
Owner Only: item control page
  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact