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N,N'-Dialkylbis(dichlorophenyl)ethylenediamines and -imidazolidines: relationship between structure and estradiol receptor affinity

Angerer, E. von and Kranzfelder, G. and Taneja, A. K. and Schönenberger, H. (1980) N,N'-Dialkylbis(dichlorophenyl)ethylenediamines and -imidazolidines: relationship between structure and estradiol receptor affinity. Journal of medicinal chemistry 23 (12), pp. 1347-1350.

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Abstract

Diastereomeric N,N'-dialkylbis(dichlorophenyl)ethylenediamines and the corresponding imidazolidines with chlorine in the 2,4, 2,6, 3,4, and 3,5 positions were synthesized. Only the stereoisomers of the 2,6-dichloro-substituted compounds exhibit for N-CH3 (2e, 3e), N-C2H5 (2f, 3f), and N-C3H7 (2g, 3g) an affinity to the estradiol receptor (Ka values ranging from 9.1 X 10(4) to 9.1 X 10(6)), ...

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Item Type:Article
Date:1980
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
7452688PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic AgentsMESH
ChemistryMESH
Ethylenediamines/chemical synthesisMESH
FemaleMESH
Mammary Neoplasms, Experimental/drug therapyMESH
MiceMESH
Organ Size/drug effectsMESH
Receptors, Estrogen/metabolismMESH
Structure-Activity RelationshipMESH
Uterus/growth & developmentMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:03 Dec 2008 15:39
Last Modified:19 Aug 2010 12:18
Item ID:4714
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