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1,1,2-triphenylbut-1-enes: relationship between structure, estradiol receptor affinity, and mammary tumor inhibiting properties

Schneider, M. R. and Angerer, E. von and Schönenberger, H. and Michel, R. T. and Fortmeyer, H. P. (1982) 1,1,2-triphenylbut-1-enes: relationship between structure, estradiol receptor affinity, and mammary tumor inhibiting properties. Journal of medicinal chemistry 25 (9), pp. 1070-7.

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Abstract

1,1,2-Triphenylbut-1-enes, which are substituted with acetoxy groups on one, two, or three aromatic rings in the para and/or meta positions, were synthesized. The identity of the occurring E and Z isomers were established by 1H NMR spectroscopy. A study on structure-activity relationships was carried out with regard to estradiol receptor affinity and to inhibiting effects on the growth of a ...

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Item Type:Article
Date:1982
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
6813499PubMed ID
Classification:
NotationType
9,10-Dimethyl-1,2-benzanthracene/toxicityMESH
Alkenes/chemical synthesisMESH
AnimalsMESH
Antineoplastic Agents/chemical synthesisMESH
ChemistryMESH
FemaleMESH
Mammary Neoplasms, Experimental/chemically inducedMESH
MiceMESH
Mice, NudeMESH
Neoplasm TransplantationMESH
RatsMESH
Receptors, EstradiolMESH
Receptors, Estrogen/metabolismMESH
Structure-Activity RelationshipMESH
Time FactorsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:03 Dec 2008 15:46
Last Modified:19 Aug 2010 12:16
Item ID:4718
Owner Only: item control page
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