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Effect of N,N'-diethyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines on the 7,12-dimethylbenz[a]anthracene-induced mammary carcinoma of the rat.

Angerer, Erwin von (1982) Effect of N,N'-diethyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines on the 7,12-dimethylbenz[a]anthracene-induced mammary carcinoma of the rat. Journal of medicinal chemistry 25 (11), pp. 1374-1377.

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Abstract

The syntheses and estrogen receptor affinities of meso- and (+/-)-N,N'-dialkyl-1,2-bis(2,6-dichloro-4-hydroxypheny)ethylenediamines (2) are described. They show high binding affinities in both diastereomeric forms but with a preference for the meso isomer, reaching a RBA value of 8.6 (meso-2b; 17 beta-estradiol = 100). Both stereoisomers of 2b exhibit a strong inhibitory effect on the ...

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Item Type:Article
Date:1982
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
6815325PubMed ID
Classification:
NotationType
9,10-Dimethyl-1,2-benzanthraceneMESH
AnimalsMESH
Antineoplastic Agents/chemical synthesisMESH
Chlorophenols/chemical synthesisMESH
Cytosol/metabolismMESH
Ethylenediamines/chemical synthesisMESH
FemaleMESH
Mammary Neoplasms, Experimental/chemically inducedMESH
MiceMESH
Organ Size/drug effectsMESH
RatsMESH
Rats, Inbred StrainsMESH
Receptors, Estrogen/metabolismMESH
Uterus/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:03 Dec 2008 15:49
Last Modified:05 Aug 2009 13:48
Item ID:4719
Owner Only: item control page
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