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2-(Hydroxyphenyl)indoles: a new class of mammary tumor inhibiting compounds

Angerer, Erwin von and Prekajac, Jelica (1983) 2-(Hydroxyphenyl)indoles: a new class of mammary tumor inhibiting compounds. Journal of medicinal chemistry 26 (1), pp. 113-116.

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Abstract

1-Alkyl-4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-6-hydroxyindoles (4, alkyl = CH3, C2H5, C3H7) were synthesized by thermolysis of the corresponding N,N'-dialkyl-1,2-diphenylethylenediamines and subsequent ether cleavage. They showed an affinity for the estrogen receptor (1% of 17 beta-estradiol) and inhibited the growth of the 9,10-dimethyl-1,2-benz[a]anthracene (DMBA) induced mammary carcinoma ...

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Export bibliographical data

Item Type:Article
Date:1983
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
6402593PubMed ID
Classification:
NotationType
9,10-Dimethyl-1,2-benzanthraceneMESH
AnimalsMESH
Antineoplastic Agents/chemical synthesisMESH
CattleMESH
Cells, CulturedMESH
ChemistryMESH
Dansyl Compounds/chemical synthesisMESH
Estradiol Congeners/chemical synthesisMESH
Estrogen Antagonists/chemical synthesisMESH
FemaleMESH
HumansMESH
Indoles/chemical synthesisMESH
Mammary Neoplasms, Experimental/chemically inducedMESH
Methotrexate/analogs & derivativesMESH
MiceMESH
RatsMESH
Rats, Inbred StrainsMESH
Uterus/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:03 Nov 2008 15:28
Last Modified:05 Aug 2009 13:48
Item ID:4721
Owner Only: item control page
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