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Benzylamines: synthesis and evaluation of antimycobacterial properties

Meindl, Wolfgang R. and Angerer, Erwin von and Schönenberger, Helmut and Ruckdeschel, Gotthard (1984) Benzylamines: synthesis and evaluation of antimycobacterial properties. Journal of medicinal chemistry 27 (9), pp. 1111-1118.

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Abstract

The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra are described. The most active compounds in this test, N-methyl-3-chlorobenzylamine (19, MIC 10.2 micrograms/mL), N-methyl-3,5-dichlorobenzylamine (93, MIC 10.2 micrograms/mL), and N-butyl-3,5-difluorobenzylamine (103, MIC 6.4 ...

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Item Type:Article
Date:1984
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
6433022PubMed ID
10.1021/jm00375a005DOI
Classification:
NotationType
Amines/pharmacologyMESH
Antitubercular Agents/pharmacologyMESH
Benzylamines/chemical synthesisMESH
Mycobacterium/drug effectsMESH
Mycobacterium tuberculosis/drug effectsMESH
Structure-Activity RelationshipMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:12 Dec 2008 17:13
Last Modified:19 Aug 2010 12:05
Item ID:4722
Owner Only: item control page
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