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The inhibitory effect of 5-acetoxy-2-(4-acetoxyphenyl)-1-ethyl-3-methylindole (D 16726) on estrogen-dependent mammary tumors

Angerer, E. von and Prekajac, J. and Berger, M. (1985) The inhibitory effect of 5-acetoxy-2-(4-acetoxyphenyl)-1-ethyl-3-methylindole (D 16726) on estrogen-dependent mammary tumors. European journal of cancer & clinical oncology 21 (4), pp. 531-537.

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Abstract

The antineoplastic activity of the antiestrogen 5-acetoxy-2-(4-acetoxyphenyl)-1-ethyl-3-methylindole (D 16726) was determined in several estrogen-dependent mammary tumor models. The growth of the DMBA-induced rat mammary carcinoma was inhibited by doses ranging from 1 to 12 mg/kg. The maximum decrease of tumor area was 67% (control + 635%). D 16726 was also active against MNU-induced rat mammary ...

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Item Type:Article
Date:1985
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:DFG Projekt An 139/1
Identification Number:
ValueType
3924626PubMed ID
Classification:
NotationType
9,10-Dimethyl-1,2-benzanthraceneMESH
AnimalsMESH
Breast Neoplasms/pathologyMESH
FemaleMESH
HumansMESH
Indoles/therapeutic useMESH
Mammary Neoplasms, Experimental/chemically inducedMESH
MethylnitrosoureaMESH
MiceMESH
Mice, Inbred StrainsMESH
Neoplasm TransplantationMESH
Neoplasms, Hormone-Dependent/drug therapyMESH
RatsMESH
Rats, Inbred StrainsMESH
Receptors, Estrogen/metabolismMESH
Tamoxifen/therapeutic useMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:11 Dec 2008 16:45
Last Modified:05 Aug 2009 13:48
Item ID:4728
Owner Only: item control page
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