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Studies on the mammary tumor-inhibiting effects of diethylstilbestrol and its mono- and diphosphate

Schneider, M. R. and Angerer, E. von and Prekajac, J. and Brade, W. P. (1986) Studies on the mammary tumor-inhibiting effects of diethylstilbestrol and its mono- and diphosphate. Journal of cancer research and clinical oncology 111 (2), pp. 110-114.

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Abstract

Diethylstilbestrol (DES), diethylstilbestrol monophosphate (DES-MP) and diethylstilbestrol diphosphate (DES-DP) were tested for their estrogen receptor affinity, estrogenic potency and mammary tumor-inhibiting activity in vitro and in vivo. DES had a much higher receptor binding affinity than its mono- or diphosphate. All three compounds inhibited the growth of the hormone-dependent MCF-7 and ...

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Item Type:Article
Date:1986
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
3754557PubMed ID
Classification:
NotationType
AnimalsMESH
Breast Neoplasms/drug therapyMESH
Cell LineMESH
Diethylstilbestrol/analogs & derivativesMESH
Dose-Response Relationship, DrugMESH
Drug Evaluation, PreclinicalMESH
Estradiol/metabolismMESH
FemaleMESH
HumansMESH
Mammary Neoplasms, Experimental/drug therapyMESH
MiceMESH
Mice, Inbred StrainsMESH
Neoplasm TransplantationMESH
Receptors, Estradiol/drug effectsMESH
Uterus/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:10 Dec 2008 15:01
Last Modified:05 Aug 2009 13:48
Item ID:4730
Owner Only: item control page
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