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Antitumor activity of antiestrogenic phenylindoles on experimental prostate tumors

Schneider, M. R. and Angerer, E. von and Höhn, W. and Sinowatz, F. (1987) Antitumor activity of antiestrogenic phenylindoles on experimental prostate tumors. European journal of cancer & clinical oncology 23 (7), pp. 1005-1015.

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Abstract

Two antiestrogenic phenylindoles (D 16726 and D 15413) were tested for their prostatic tumor-inhibiting activity. Both compounds exerted a strong inhibitory effect on prostate and seminal vesicle weight of intact rats and mice comparable to that of diethylstilbestrol. Their estrogenic properties, however, are much lower than those of DES. Therefore, there is no direct correlation between ...

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Item Type:Article
Date:1987
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
3665986PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/therapeutic useMESH
CastrationMESH
Cell Division/drug effectsMESH
Estrogen Antagonists/therapeutic useMESH
Indoles/therapeutic useMESH
MaleMESH
MiceMESH
Mice, Inbred BALB CMESH
Neoplasms, Hormone-Dependent/drug therapyMESH
Organ SizeMESH
Prostatic Neoplasms/drug therapyMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:10 Dec 2008 15:22
Last Modified:05 Aug 2009 13:48
Item ID:4733
Owner Only: item control page
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