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Platinum complexes with binding affinity for the estrogen receptor

Knebel, N. and Angerer, E. von (1988) Platinum complexes with binding affinity for the estrogen receptor. Journal of medicinal chemistry 31 (9), pp. 1675-1679.

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Abstract

A number of (1,2-diaminoethane)dichloroplatinum(II) complexes, linked to dihydroxy-2-phenylindole by spacer groups of varying lengths, were synthesized and studied for their binding affinities for the calf uterine estrogen receptor. Best binding conditions were provided by the n-hexyl and the p-xylene group as spacer with RBA values of 6.5 (16c) and 4.4 (17c), respectively (17 beta-estradiol: RBA ...

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Item Type:Article
Date:1988
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
3411596PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic AgentsMESH
Binding, CompetitiveMESH
CattleMESH
ChemistryMESH
Cytosol/metabolismMESH
Estradiol/metabolismMESH
FemaleMESH
Organoplatinum Compounds/chemical synthesisMESH
Receptors, Estrogen/metabolismMESH
Uterus/metabolismMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:10 Dec 2008 15:07
Last Modified:05 Aug 2009 13:48
Item ID:4736
Owner Only: item control page
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