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Carrier mediated action of platinum complexes on estrogen receptor positive tumors

Knebel, N. and Schiller, C. D. and Schneider, M. R. and Schönenberger, H. and Angerer, E. von (1989) Carrier mediated action of platinum complexes on estrogen receptor positive tumors. European journal of cancer & clinical oncology 25 (2), pp. 293-299.

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Abstract

Three 1,2-diaminoethane-dichloro-platinum(II) complexes linked to 5-hydroxy-2-(4-hydroxyphenyl)-3-methylindole by spacer groups of varying length were evaluated for cytostatic activity in estrogen receptor (ER) positive and negative tumor cells. In vitro, only the growth of ER positive MCF-7 mammary tumor cells was inhibited whereas hormone independent MDA-MB 231 cells did not respond. In vivo, a ...

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Item Type:Article
Date:1989
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
2702983PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/therapeutic useMESH
Breast Neoplasms/drug therapyMESH
Drug CarriersMESH
FemaleMESH
HumansMESH
MaleMESH
Mammary Neoplasms, Experimental/analysisMESH
MiceMESH
Mice, Inbred StrainsMESH
Organ Size/drug effectsMESH
Organoplatinum Compounds/therapeutic useMESH
Prostatic Neoplasms/drug therapyMESH
Receptors, Estrogen/analysisMESH
Tumor Cells, Cultured/drug effectsMESH
Uterus/pathologyMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:11 Dec 2008 15:47
Last Modified:19 Aug 2010 12:02
Item ID:4737
Owner Only: item control page
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