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Platinum complexes with a selective action on estrogen receptor-positive mammary tumors

Angerer, E. von and Birnböck, H. and Knebel, N. (1989) Platinum complexes with a selective action on estrogen receptor-positive mammary tumors. Anti-cancer drug design 4 (1), pp. 21-35.

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Abstract

Four (1,3-diaminopropane)dichloroplatinum(II) complexes, linked to 5-hydroxy-2-(4-hydroxyphenyl)-3-methylindole by spacer groups of varying lengths, were synthesized and studied for their binding affinities for the calf uterine estrogen receptor. The RBA-values ranged from 1.0 to 4.4 (estradiol: RBA = 100). The endocrine activities of the complexes and their ligands, determined in the mouse ...

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Item Type:Article
Date:1989
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
2757751PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/chemical synthesisMESH
Breast Neoplasms/metabolismMESH
CattleMESH
ChemistryMESH
Drug Screening Assays, AntitumorMESH
FemaleMESH
HumansMESH
Mammary Neoplasms, Experimental/analysisMESH
MiceMESH
Mice, Inbred StrainsMESH
Neoplasm TransplantationMESH
Organ Size/drug effectsMESH
Organoplatinum Compounds/chemical synthesisMESH
RatsMESH
Rats, Inbred StrainsMESH
Receptors, Estrogen/analysisMESH
Remission InductionMESH
Tumor Cells, Cultured/drug effectsMESH
Uterus/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:10 Dec 2008 15:46
Last Modified:05 Aug 2009 13:48
Item ID:4738
Owner Only: item control page
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