Birnböck, H. and Angerer, E. von (1990) Sulfate derivatives of 2-phenylindoles as novel steroid sulfatase inhibitors. An in vitro study on structure-activity-relationship. Biochemical pharmacology 39 (11), pp. 1709-1713.
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The growth of hormone-dependent mammary tumor cells is stimulated by non-conjugated estrogens. One important source of these hormones in the tumors could be the enzymatic hydrolysis of circulating estrogen sulfates by steroid sulfatase (EC 188.8.131.52). Inhibition of this enzyme may result in reduced levels of endogenous estrogens and, consequently, in a reduced proliferation rate of ...
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|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)|
|Subjects:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||10 Dec 2008 14:46|
|Last Modified:||05 Aug 2009 13:48|