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Sulfate derivatives of 2-phenylindoles as novel steroid sulfatase inhibitors. An in vitro study on structure-activity-relationship

Birnböck, H. and Angerer, E. von (1990) Sulfate derivatives of 2-phenylindoles as novel steroid sulfatase inhibitors. An in vitro study on structure-activity-relationship. Biochemical pharmacology 39 (11), pp. 1709-1713.

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Abstract

The growth of hormone-dependent mammary tumor cells is stimulated by non-conjugated estrogens. One important source of these hormones in the tumors could be the enzymatic hydrolysis of circulating estrogen sulfates by steroid sulfatase (EC 3.1.6.2). Inhibition of this enzyme may result in reduced levels of endogenous estrogens and, consequently, in a reduced proliferation rate of ...

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Item Type:Article
Date:1990
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
2344367PubMed ID
Classification:
NotationType
AnimalsMESH
Arylsulfatases/antagonists & inhibitorsMESH
CattleMESH
ChemistryMESH
Indoles/pharmacologyMESH
Molecular StructureMESH
Steryl-SulfataseMESH
Structure-Activity RelationshipMESH
Sulfatases/antagonists & inhibitorsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:10 Dec 2008 14:46
Last Modified:05 Aug 2009 13:48
Item ID:4740
Owner Only: item control page
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