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2-phenylindole-linked nitroimidazoles as potential radiosensitizers for estrogen receptor positive tumors

Erber, Sebastian and Angerer, Erwin von (1990) 2-phenylindole-linked nitroimidazoles as potential radiosensitizers for estrogen receptor positive tumors. Archiv der Pharmazie 323 (9), pp. 591-594.

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Abstract

5-Hydroxy-2-(4-hydroxyphenyl)-3-methylindole was linked to nitroimidazoles by tetramethylene and hexamethylene spacer groups. Derivatives with a C₆-spacer (4c and 4d) exhibited high binding affinities for the estrogen receptor (RBA = 3.5; estradiol: 100), a prerequisite for a selective uptake by estrogen receptor positive tumors. Both compounds inhibited the growth of hormone-sensitive human ...

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Item Type:Article
Date:1990
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
2288481PubMed ID
10.1002/ardp.19903230907DOI
Classification:
NotationType
AnimalsMESH
Breast Neoplasms/metabolismMESH
Cell Division/drug effectsMESH
FemaleMESH
HumansMESH
Indoles/chemical synthesisMESH
MiceMESH
Neoplasms, Hormone-Dependent/metabolismMESH
Nitroimidazoles/chemical synthesisMESH
Radiation-Sensitizing Agents/chemical synthesisMESH
Receptors, Estrogen/drug effectsMESH
Tumor Cells, Cultured/drug effectsMESH
Uterus/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:03 Nov 2008 15:34
Last Modified:05 Aug 2009 13:48
Item ID:4742
Owner Only: item control page
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