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3-(Cyclohexenonyl)-4-(4-hydroxyphenyl)-hexanes: antiandrogenes derived from the estrogen hexestrol

Schiller, Claus D. and Schneider, Martin R. and Angerer, Erwin von (1990) 3-(Cyclohexenonyl)-4-(4-hydroxyphenyl)-hexanes: antiandrogenes derived from the estrogen hexestrol. Archiv der Pharmazie 323 (7), pp. 417-420.

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Abstract

Selective Birch-reduction of one of the phenolic rings of meso- or d,l-HES led to compounds 6a and 6b which exert a higher binding affinity to the androgen receptor as the respective parent HES. In vivo testing of 6a and 6b shows that 6a has the same potency in reducing accessory sex organ weights and testosterone levels in the intact mouse as has meso-HES, but strongly decreased estrogenic ...

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Item Type:Article
Date:1990
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
2173517PubMed ID
Classification:
NotationType
Androgen Antagonists/chemical synthesisMESH
AnimalsMESH
FemaleMESH
Hexestrol/analogs & derivativesMESH
MaleMESH
MiceMESH
Organ Size/drug effectsMESH
RabbitsMESH
Testosterone/bloodMESH
Uterus/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:11 Dec 2008 17:02
Last Modified:05 Aug 2009 13:48
Item ID:4743
Owner Only: item control page
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