Angerer, E. von and Knebel, N. and Kager, M. and Ganss, B. (1990) 1-(aminoalkyl)-2-phenylindoles as novel pure estrogen antagonists. Journal of medicinal chemistry 33 (9), pp. 2635-2640.
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A number of 1-(omega-aminoalkyl)-5-hydroxy-2-(4-hydroxyphenyl)indoles were synthesized and studied for their binding affinities for the calf uterine estrogen receptor and estrogen antagonistic activities. Highest binding affinities were found with derivatives bearing a methyl group in position 3 and a hexamethylene chain between the indole and amino nitrogen atoms. Values for relative binding ...
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|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)|
|Subjects:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||10 Dec 2008 14:45|
|Last Modified:||05 Aug 2009 13:48|