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1-(aminoalkyl)-2-phenylindoles as novel pure estrogen antagonists

Angerer, E. von and Knebel, N. and Kager, M. and Ganss, B. (1990) 1-(aminoalkyl)-2-phenylindoles as novel pure estrogen antagonists. Journal of medicinal chemistry 33 (9), pp. 2635-2640.

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Abstract

A number of 1-(omega-aminoalkyl)-5-hydroxy-2-(4-hydroxyphenyl)indoles were synthesized and studied for their binding affinities for the calf uterine estrogen receptor and estrogen antagonistic activities. Highest binding affinities were found with derivatives bearing a methyl group in position 3 and a hexamethylene chain between the indole and amino nitrogen atoms. Values for relative binding ...

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Item Type:Article
Date:1990
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
2391702PubMed ID
Classification:
NotationType
Amines/chemical synthesisMESH
AnimalsMESH
Binding SitesMESH
CattleMESH
ChemistryMESH
Estrogen Antagonists/chemical synthesisMESH
FemaleMESH
Indoles/chemical synthesisMESH
MiceMESH
Morpholines/chemical synthesisMESH
Piperidines/chemical synthesisMESH
Pyrrolidines/chemical synthesisMESH
Receptors, Estrogen/drug effectsMESH
Structure-Activity RelationshipMESH
Uterus/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:10 Dec 2008 14:45
Last Modified:05 Aug 2009 13:48
Item ID:4745
Owner Only: item control page
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