Startseite UB

2-Phenylbenzo[b]furans: relationship between structure, estrogen receptor affinity and cytostatic activity against mammary tumor cells

Erber, S. and Ringshandl, R. and Angerer, E. von (1991) 2-Phenylbenzo[b]furans: relationship between structure, estrogen receptor affinity and cytostatic activity against mammary tumor cells. Anti-cancer drug design 6 (5), pp. 417-426.

Full text not available from this repository.

at PubMed


Abstract

A number of 2-(4-hydroxyphenyl)benzo[b]furans with a hydroxy group in position 5 or 6 and a short alkyl group at C-3 were synthesized from appropriate 1,2-diarylethanones and studied for their estrogen receptor affinity. The relative binding affinities in the 5-hydroxy series were higher than those of 6-hydroxy derivatives by a factor of 10. The trifluoroethyl and the propyl derivatives displayed ...

plus


Export bibliographical data



Item Type:Article
Date:1991
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
1764164PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/metabolismMESH
Benzofurans/metabolismMESH
Breast Neoplasms/drug therapyMESH
CattleMESH
Cell Survival/drug effectsMESH
Estradiol/metabolismMESH
FemaleMESH
HumansMESH
Mammary Neoplasms, Experimental/drug therapyMESH
MiceMESH
Mice, Inbred StrainsMESH
Neoplasms, Hormone-Dependent/drug therapyMESH
Receptors, Estrogen/metabolismMESH
Structure-Activity RelationshipMESH
Tumor Cells, Cultured/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:10 Dec 2008 14:39
Last Modified:05 Aug 2009 13:48
Item ID:4747
Owner Only: item control page
  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact