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Pharmacological characterization of a novel oestrogen antagonist, ZK 119010, in rats and mice

Nishino, Y. and Schneider, M. R. and Michna, H. and Angerer, E. von (1991) Pharmacological characterization of a novel oestrogen antagonist, ZK 119010, in rats and mice. The Journal of endocrinology 130 (3), pp. 409-414.

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Abstract

The oestrogenic and antioestrogenic effects of a new nonsteroidal compound ZK 119010 (2-(4-hydroxyphenyl)-3-methyl-1-[6-(1-pyrrolidinyl)-hexyl]-indol-5-ol) were evaluated and compared with those of tamoxifen and ICI 164384. In immature mice, ZK 119010 administered once daily for 3 days (s.c.) inhibited the uterotrophic and vaginotrophic effect of oestradiol in a dose-dependent manner and was ...

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Item Type:Article
Date:1991
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
1834757PubMed ID
Classification:
NotationType
AnimalsMESH
Drug Evaluation, Preclinical/methodsMESH
Estradiol/analogs & derivativesMESH
Estrogen Antagonists/pharmacologyMESH
FemaleMESH
MiceMESH
Mice, Inbred StrainsMESH
Organ Size/drug effectsMESH
OvariectomyMESH
Polyunsaturated AlkamidesMESH
RatsMESH
Rats, Inbred StrainsMESH
Specific Pathogen-Free OrganismsMESH
Tamoxifen/pharmacologyMESH
Uterus/drug effectsMESH
Vagina/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Owner: Prof. Armin Buschauer
Deposited On:11 Dec 2008 16:56
Last Modified:05 Aug 2009 13:48
Item ID:4749
Owner Only: item control page
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