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Antiproliferative activity of casodex (ICI 176.334) in hormone-dependent tumours

Maucher, A. and Angerer, E. von (1993) Antiproliferative activity of casodex (ICI 176.334) in hormone-dependent tumours. Journal of cancer research and clinical oncology 119 (11), pp. 669-674.

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Abstract

The nonsteroidal antiandrogen casodex has been described as a peripherally selective drug for the treatment of prostatic cancer. In this study we determined its activity in various models of hormone-dependent malignancies including those of the prostate and the breast. Analysis of endocrine effects in rats after 15 days of treatment revealed a strong reduction of the weights of prostates and ...

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Item Type:Article
Date:1993
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
8349724PubMed ID
10.1007/BF01215986DOI
Classification:
NotationType
Androgen Antagonists/pharmacologyMESH
Anilides/pharmacologyMESH
AnimalsMESH
Antineoplastic Agents/pharmacologyMESH
Antineoplastic Combined Chemotherapy Protocols/therapeutic useMESH
Cell Division/drug effectsMESH
Diethylstilbestrol/therapeutic useMESH
FemaleMESH
Flutamide/pharmacologyMESH
MaleMESH
Mammary Neoplasms, Experimental/drug therapyMESH
MiceMESH
Neoplasms, Hormone-Dependent/drug therapyMESH
NitrilesMESH
Prostatic Neoplasms/drug therapyMESH
RatsMESH
Rats, Inbred F344MESH
Receptors, Androgen/metabolismMESH
Testosterone/antagonists & inhibitorsMESH
Tosyl CompoundsMESH
Tumor Cells, Cultured/drug effectsMESH
Keywords:Nonsteroidal antiandrogen; LNCaP prostate carcinoma cells; Dunning R3327-G tumour; MXT mouse mammary tumour
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:01 Dec 2008 16:54
Last Modified:05 Aug 2009 13:48
Item ID:4758
Owner Only: item control page
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