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A rapid luciferase transfection assay for transcription activation effects and stability control of estrogenic drugs in cell cultures

Meyer, T. and Koop, R. and Angerer, E. von and Schönenberger, H. and Holler, E. (1994) A rapid luciferase transfection assay for transcription activation effects and stability control of estrogenic drugs in cell cultures. Journal of Cancer Research and Clinical Oncology 120 (6), pp. 359-364.

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Abstract

A rapid assay system for measuring the potential of estrogenic drugs is introduced. Luciferase induction could be measured in estrogen-receptor-positive human MCF-7 breast cancer cells, which had been transfected with a novel luciferase reporter plasmid ERE luc. The minimal requirement was 1 h exposure to the inducing drug and 3.5 h of incubation after removal of the drug. The assay system was ...

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Item Type:Article
Date:1994
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:DFG Projekt An 139/3
Identification Number:
ValueType
8138561PubMed ID
Classification:
NotationType
Antineoplastic Agents/pharmacologyMESH
Breast Neoplasms/metabolismMESH
Enzyme Activation/drug effectsMESH
Estradiol/pharmacologyMESH
Estrogens, Non-Steroidal/pharmacologyMESH
FemaleMESH
HumansMESH
Luciferases/geneticsMESH
Organoplatinum Compounds/pharmacologyMESH
Receptors, Estrogen/drug effectsMESH
Transcription, Genetic/drug effectsMESH
TransfectionMESH
Tumor Cells, CulturedMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:12 Dec 2008 16:20
Last Modified:19 Aug 2010 11:41
Item ID:4763
Owner Only: item control page
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