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Dibenzo[a,f]quinolizines: syntheses and cytostatic activity in estrogen-sensitive tumor cells

Angerer, S. von and Seidl, E. and Mannschreck, A. and Angerer, E. von and Wiegrebe, Wolfgang (1994) Dibenzo[a,f]quinolizines: syntheses and cytostatic activity in estrogen-sensitive tumor cells. Anti-cancer drug design 9 (1), pp. 25-40.

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Abstract

A number of methoxy-substituted 7,11b,12,13-tetrahydro-6H-dibenzo-[a,f]quinolizines with short alkyl groups in position 6 or 12 were synthesized by the Bischler-Napieralski reaction using the appropriate starting material followed by a second ring closure reaction involving a base-generated benzyne intermediate. The methoxy functions in positions 2 or 3 and 9 were cleaved with BBr3 and the free ...

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Item Type:Article
Date:1994
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
8141964PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/chemical synthesisMESH
Estrogens/pharmacologyMESH
FemaleMESH
HumansMESH
Mammary Neoplasms, Experimental/drug therapyMESH
MiceMESH
Neoplasms, Hormone-Dependent/drug therapyMESH
Quinolizines/chemical synthesisMESH
Receptors, Estrogen/metabolismMESH
Structure-Activity RelationshipMESH
Tumor Cells, Cultured/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:10 Dec 2008 16:33
Last Modified:13 Mar 2014 13:50
Item ID:4766
Owner Only: item control page
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