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Studies on heterocycle-based pure estrogen antagonists

Angerer, E. von and Biberger, C. and Leichtl, S. (1995) Studies on heterocycle-based pure estrogen antagonists. Annals of the New York Academy of Sciences 761, pp. 176-191.

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Abstract

2-Phenylindoles and isosteric structures such as benzo[b]furans and benzo[b]thiophenes were used as estrogen receptor binding moiety for the syntheses of new nonsteroidal antiestrogens. The antiestrogenic potency was considerably enhanced following the introduction of polar functional groups into the side chain in position 1 (indole) or 3 (benzofuran, benzothiophene). The amino compounds could be ...

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Item Type:Article
Date:1995
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:DFG Projekt An 139/4
Identification Number:
ValueType
7625720PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/pharmacologyMESH
Breast Neoplasms/drug therapyMESH
Drug ResistanceMESH
Endocrine Glands/drug effectsMESH
Estrogen Antagonists/chemistryMESH
FemaleMESH
Hela CellsMESH
HumansMESH
MiceMESH
Receptors, Estrogen/metabolismMESH
Structure-Activity RelationshipMESH
Tamoxifen/pharmacologyMESH
Trans-Activation (Genetics)/drug effectsMESH
Tumor Cells, CulturedMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:11 Dec 2008 15:30
Last Modified:27 Aug 2012 11:51
Item ID:4767
Owner Only: item control page
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