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2-Phenylindoles with sulfur containing side chains. Estrogen receptor affinity, antiestrogenic potency, and antitumor activity

Biberger, C. and Angerer, E. von (1996) 2-Phenylindoles with sulfur containing side chains. Estrogen receptor affinity, antiestrogenic potency, and antitumor activity. The Journal of Steroid Biochemistry and Molecular Biology 58 (1), pp. 31-43.

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Abstract

The 2-phenylindole system has been identified as a suitable structure for the design of non-steroidal pure estrogen antagonists [E. von Angerer et al., J. Steroid Biochem. Molec. Biol. 49 (1994) 51-62]. Derivatives with an amide function in the side chain antagonized the stimulatory effect of estrogens both in vitro and in vivo, and showed no agonistic activity when given alone. The findings of ...

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Item Type:Article
Date:1996
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:DFG Projekt An 139/4
Identification Number:
ValueType
8809184PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents, Hormonal/chemical synthesisMESH
Breast NeoplasmsMESH
CattleMESH
Cell Division/drug effectsMESH
Estradiol/analogs & derivativesMESH
Estrogen Antagonists/chemical synthesisMESH
Estrone/pharmacologyMESH
FemaleMESH
Hela CellsMESH
HumansMESH
Indoles/chemical synthesisMESH
Mammary Neoplasms, Experimental/drug therapyMESH
MiceMESH
Organ Size/drug effectsMESH
Receptors, Estrogen/geneticsMESH
Sulfur/chemistryMESH
Tamoxifen/therapeutic useMESH
Trans-Activation (Genetics)MESH
Tumor Cells, CulturedMESH
Uterus/growth & developmentMESH
Vitellogenins/geneticsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:11 Dec 2008 15:20
Last Modified:05 Aug 2009 13:48
Item ID:4768
Owner Only: item control page
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