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Effect of growth factors on estrogen receptor mediated gene expression

Hafner, F. and Holler, E. and Angerer, E. von (1996) Effect of growth factors on estrogen receptor mediated gene expression. The Journal of Steroid Biochemistry and Molecular Biology 58 (4), pp. 385-393.

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Abstract

The proliferation of mammary carcinoma cells can be stimulated by estrogens and various growth factors such as EGF and IGF-I. Steroid hormones and growth factors are understood to exert their effects via different receptors and signal transduction pathways. Recently, it has been shown that growth factors can utilize the unliganded estrogen receptor (ER) as a transcription factor. This study was ...

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Item Type:Article
Date:1996
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:Graduiertenkolleg Therapieforschung Onkologie
Identification Number:
ValueType
8903422PubMed ID
Classification:
NotationType
Breast NeoplasmsMESH
CarcinomaMESH
Cell DivisionMESH
Epidermal Growth Factor/pharmacologyMESH
Estradiol/analogs & derivativesMESH
Estrogen Antagonists/pharmacologyMESH
Gene Expression Regulation, Neoplastic/drug effectsMESH
Genes, Reporter/geneticsMESH
Growth Substances/pharmacologyMESH
Hela CellsMESH
HumansMESH
Insulin/pharmacologyMESH
Insulin-Like Growth Factor I/pharmacologyMESH
Luciferases/biosynthesisMESH
Receptors, Estrogen/geneticsMESH
TransfectionMESH
Tumor Cells, CulturedMESH
Vitellogenins/geneticsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:11 Dec 2008 15:10
Last Modified:05 Aug 2009 13:48
Item ID:4769
Owner Only: item control page
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