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Inhibition of tubulin polymerization by 5,6-dihydroindolo[2,1-alpha]isoquinoline derivatives

Goldbrunner, M. and Loidl, G. and Polossek, T. and Mannschreck, A. and Angerer, E. von (1997) Inhibition of tubulin polymerization by 5,6-dihydroindolo[2,1-alpha]isoquinoline derivatives. Journal of Medicinal Chemistry 40 (22), pp. 3524-3533.

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Abstract

6-Alkyl-12-formyl-5,6-dihydroindolo[2,1-alpha]isoquinolines have been shown to inhibit the growth of human mammary carcinoma cells by an unknown mode of action. One of the possible molecular targets is the tubulin system which is involved in cell division. A number of 5,6-dihydroindolo[2,1-alpha]isoquinolines with methoxy or hydroxy groups in positions 3, 9, and/or 10 and various functional ...

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Item Type:Article
Date:1997
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
9357519PubMed ID
10.1021/jm970177cDOI
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/chemistryMESH
CattleMESH
Colchicine/metabolismMESH
HumansMESH
Indoles/chemistryMESH
Isoquinolines/chemistryMESH
Magnetic Resonance SpectroscopyMESH
Molecular StructureMESH
PolymersMESH
Protein BindingMESH
Spectrophotometry, InfraredMESH
Tubulin/metabolismMESH
Tubulin ModulatorsMESH
Tumor Cells, CulturedMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:03 Dec 2008 15:22
Last Modified:05 Aug 2009 13:48
Item ID:4771
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