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1-Benzyl-2-phenylindole- and 1,2-diphenylindole-based antiestrogens. Estimation of agonist and antagonist activities in transfection assays

Biberger, C. and Angerer, E. von (1998) 1-Benzyl-2-phenylindole- and 1,2-diphenylindole-based antiestrogens. Estimation of agonist and antagonist activities in transfection assays. The Journal of Steroid Biochemistry and Molecular Biology 64 (5-6), pp. 277-285.

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Abstract

In the 2-phenylindole system, the side chain at the nitrogen atom dominates the endocrine profile both in respect to the reduction of estrogenic action and the increase of antiestrogenic potency. In previous papers we reported on 2-phenylindoles with aliphatic side chains and various functional groups [Biberger, C. and von Angerer, E., J. Steroid Biochem. Molec. Biol., 1996, 58, 31-43 and ...

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Item Type:Article
Date:1998
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:DFG Projekt An 139/4
Identification Number:
ValueType
9618029PubMed ID
Classification:
NotationType
Cell Division/drug effectsMESH
Estradiol Antagonists/chemical synthesisMESH
Estrogen Antagonists/chemical synthesisMESH
Estrogens/pharmacologyMESH
Gene Expression Regulation/drug effectsMESH
Genes, Reporter/geneticsMESH
HumansMESH
Indoles/chemical synthesisMESH
Magnetic Resonance SpectroscopyMESH
Molecular StructureMESH
Protein Binding/physiologyMESH
Receptors, Estrogen/antagonists & inhibitorsMESH
Transcription, Genetic/drug effectsMESH
Transfection/geneticsMESH
Tumor Cells, CulturedMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:12 Dec 2008 16:41
Last Modified:05 Aug 2009 13:48
Item ID:4772
Owner Only: item control page
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