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Methoxy-substituted 3-formyl-2-phenylindoles inhibit tubulin polymerization

Gastpar, R. and Goldbrunner, M. and Marko, D. and Angerer, E. von (1998) Methoxy-substituted 3-formyl-2-phenylindoles inhibit tubulin polymerization. Journal of Medicinal Chemistry 41 (25), pp. 4965-4972.

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Abstract

The aim of this study was the identification of the essential structural elements in the 12-formyl-5,6-dihydroindolo[2, 1-a]isoquinoline system required for the inhibition of tubulin polymerization which is understood to be the predominant mode of action of this class of cytostatics. Since 2-phenylindole forms the main fragment of this tetracycle, it was used as the basic structure and modified ...

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Item Type:Article
Date:1998
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
9836614PubMed ID
10.1021/jm980228lDOI
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/chemical synthesisMESH
BiopolymersMESH
Brain/metabolismMESH
Breast Neoplasms/pathologyMESH
CattleMESH
Colchicine/metabolismMESH
Drug Screening Assays, AntitumorMESH
FemaleMESH
HumansMESH
Indoles/chemical synthesisMESH
Inhibitory Concentration 50MESH
Microscopy, FluorescenceMESH
Neoplasms, Hormone-Dependent/pathologyMESH
Protein BindingMESH
Structure-Activity RelationshipMESH
Tubulin/metabolismMESH
Tubulin ModulatorsMESH
Tumor Cells, CulturedMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:03 Dec 2008 15:34
Last Modified:05 Aug 2009 13:48
Item ID:4773
Owner Only: item control page
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