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2-Phenylbenzo[b]thiophene-based antiestrogens with mammary tumor inhibiting activity

Leichtl, S. and Angerer, E. von (1998) 2-Phenylbenzo[b]thiophene-based antiestrogens with mammary tumor inhibiting activity. Archiv der Pharmazie 331 (9), pp. 283-289.

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Abstract

In this study we extended our studies on heterocyclic antiestrogens to 2-phenylbenzo[b]thiophenes which can be considered as isosteric to the 2-phenylindole system. We synthesized a number of 6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophenes with carbamoyl and amino functions in the side chain at carbon-3 and analyzed their biological properties. The binding affinities for the estrogen receptor are ...

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Item Type:Article
Date:1998
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:DFG Projekt An 139/4
Identification Number:
ValueType
9793483PubMed ID
10.1002/(SICI)1521-4184(19989)331:9<283::AID-ARDP283>3.0.CO;2-NDOI
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents, Hormonal/chemical synthesisMESH
Breast Neoplasms/drug therapyMESH
Drug Screening Assays, AntitumorMESH
Estrogen Antagonists/chemical synthesisMESH
HumansMESH
MiceMESH
Thiophenes/chemical synthesisMESH
Tumor Cells, CulturedMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:11 Dec 2008 16:59
Last Modified:27 Aug 2012 11:51
Item ID:4774
Owner Only: item control page
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