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The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor

Meiers, S. and Kemény, M. and Weyand, U. and Gastpar, R. and Angerer, E. von and Marko, D. (2001) The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor. Journal of Agricultural and Food Chemistry 49 (2), pp. 958-962.

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Abstract

The aglycons of the most abundant anthocyanins in food, cyanidin (cy) and delphinidin (del), were found to inhibit the growth of human tumor cells in vitro in the micromolar range, whereas malvidin (mv), a typical anthocyanidin in grapes, was less active. The aglycons preferentially inhibited the growth of the human vulva carcinoma cell line A431, overexpressing the epidermal growth-factor ...

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Item Type:Article
Date:2001
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
11262056PubMed ID
Classification:
NotationType
AnimalsMESH
Anthocyanins/pharmacologyMESH
Benzopyrans/pharmacologyMESH
Carcinoma, Large CellMESH
Cell Division/drug effectsMESH
FemaleMESH
HumansMESH
Lung NeoplasmsMESH
Protein-Tyrosine Kinases/antagonists & inhibitorsMESH
Receptor, Epidermal Growth Factor/antagonists & inhibitorsMESH
RosalesMESH
TransfectionMESH
Transplantation, HeterologousMESH
Tumor Cells, CulturedMESH
Vulvar NeoplasmsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Owner: Prof. Armin Buschauer
Deposited On:03 Dec 2008 15:36
Last Modified:05 Aug 2009 13:48
Item ID:4776
Owner Only: item control page
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