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Stilbene-based inhibitors of estrone sulfatase with a dual mode of action in human breast cancer cells

Walter, Georg and Liebl, Renate and Angerer, Erwin von (2004) Stilbene-based inhibitors of estrone sulfatase with a dual mode of action in human breast cancer cells. Archiv der Pharmazie 337 (12), pp. 634-644.

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Abstract

Estrone sulfate (E1S) is an endogenous prodrug that delivers estrone and, subsequently, estradiol to target cells, after hydrolysis by the enzyme estrone sulfatase, which is active in various tissues including hormone-dependent breast cancer. Blockade of this enzyme should reduce the estrogen level in breast cancer cells and prevent hormonal growth stimulation. In this study, a number of ...

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Item Type:Article
Date:2004
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:DFG Projekt An 139/6
Identification Number:
ValueType
15597397PubMed ID
10.1002/ardp.200400904DOI
Classification:
NotationType
Breast Neoplasms/enzymologyMESH
Cell Line, TumorMESH
Cell Proliferation/drug effectsMESH
Enzyme Inhibitors/chemical synthesisMESH
Estrogen Receptor Modulators/chemical synthesisMESH
HumansMESH
Molecular StructureMESH
Protein BindingMESH
Radioligand AssayMESH
Receptors, Estrogen/metabolismMESH
Stilbenes/chemical synthesisMESH
Structure-Activity RelationshipMESH
Sulfatases/antagonists & inhibitorsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:11 Dec 2008 15:22
Last Modified:05 Aug 2009 13:48
Item ID:4779
Owner Only: item control page
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