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Antimitotic activities of 2-phenylindole-3-carbaldehydes in human breast cancer cells

Kaufmann, Doris and Pojarová, Michaela and Vogel, Susanne and Liebl, Renate and Gastpar, Robert and Gross, Dietmar and Nishino, Tsuyuki and Pfaller, Tobias and Angerer, Erwin von (2007) Antimitotic activities of 2-phenylindole-3-carbaldehydes in human breast cancer cells. Bioorganic & medicinal chemistry 15 (15), pp. 5122-36.

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Abstract

Small molecules such as indoles are attractive as inhibitors of tubulin polymerization. Thus a number of 2-phenylindole-3-carbaldehydes with lipophilic substituents in both aromatic rings was synthesized and evaluated for antitumor activity in MDA-MB 231 and MCF-7 breast cancer cells. Some 5-alkylindole derivatives with a 4-methoxy group in the 2-phenyl ring strongly inhibit the growth of breast ...

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Item Type:Article
Date:2007
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
17533132PubMed ID
10.1016/j.bmc.2007.05.030DOI
Classification:
NotationType
Aldehydes/chemistryMESH
Antineoplastic Agents/chemistryMESH
Breast Neoplasms/drug therapyMESH
Cell Line, TumorMESH
Cell Proliferation/drug effectsMESH
Cell Shape/drug effectsMESH
Cells/drug effectsMESH
HumansMESH
Mitosis/drug effectsMESH
Molecular StructureMESH
Structure-Activity RelationshipMESH
Time FactorsMESH
Tubulin/metabolismMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:03 Dec 2008 15:29
Last Modified:05 Aug 2009 13:48
Item ID:4784
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