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Platinum(II) complexes interfering with testicular steroid biosynthesis: drugs for the therapy of advanced or recurrent prostate cancers? Preclinical studies

Schertl, Sabine and Hartmann, Rolf W. and Batzl-Hartmann, Christine and Spruss, Thilo and Maucher, Anton and Angerer, Erwin von and Schiller, Claus D. and Schneider, Martin R. and Gust, Ronald and Schönenberger, Helmut (2007) Platinum(II) complexes interfering with testicular steroid biosynthesis: drugs for the therapy of advanced or recurrent prostate cancers? Preclinical studies. Journal of Cancer Research and Clinical Oncology 133 (3), pp. 153-167.

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Abstract

[Meso-1,2-bis(2,6-dihalo-3/4-hydroxyphenyl)ethylenediamine]platinum(II) complexes (meso-1-PtLL': 2,6-F(2),3-OH; meso-2-PtLL': 2,6-F(2),4-OH; meso-3-PtLL': 2,6-Cl(2),3-OH; meso-4-PtLL': 2,6-Cl(2),4-OH; L = OH(2), L' = OSO(3) or L,L' = Cl(2)) were designed with the aim to get drugs comprising both cytotoxic and testosterone level lowering potencies. It is assumed that such compounds are more ...

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Item Type:Article
Date:2007
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
17024493PubMed ID
10.1007/s00432-006-0151-3DOI
Classification:
NotationType
Androgen Antagonists/pharmacologyMESH
AnimalsMESH
Antineoplastic Agents, Hormonal/pharmacologyMESH
Cell Line, TumorMESH
Cell Survival/drug effectsMESH
Diethylstilbestrol/pharmacologyMESH
Dose-Response Relationship, DrugMESH
Furans/pharmacologyMESH
HumansMESH
Lymphatic MetastasisMESH
MaleMESH
Middle AgedMESH
Neoplasm Recurrence, Local/prevention & controlMESH
Neoplasms, Hormone-Dependent/drug therapyMESH
Organ Size/drug effectsMESH
Organoplatinum Compounds/pharmacologyMESH
Prostatic Neoplasms/drug therapyMESH
Pyrones/pharmacologyMESH
RatsMESH
Rats, Sprague-DawleyMESH
Testis/drug effectsMESH
Testosterone/antagonists & inhibitorsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:03 Dec 2008 15:24
Last Modified:19 Aug 2010 11:12
Item ID:4785
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