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Estrogenic and antiestrogenic activities of 2,4-diphenylfuran-based ligands of estrogen receptors α and β

Zimmermann, Jochen and Angerer, Erwin von (2007) Estrogenic and antiestrogenic activities of 2,4-diphenylfuran-based ligands of estrogen receptors α and β. The Journal of Steroid Biochemistry and Molecular Biology 104 (3-5), pp. 259-268.

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Abstract

The estrogen receptor (ER) exists in two isoforms ERα and ERβ with a different distribution in the body and different functions which are not clearly identified yet. Thus, it is desirable to have both agonists and antagonists with selectivity for one or the other ER isoform available. In a previous study we showed that 2,5-diphenylfurans can be converted into pure antiestrogens with preference ...

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Item Type:Article
Date:2007
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
17475477PubMed ID
10.1016/j.jsbmb.2007.03.022DOI
Classification:
NotationType
Breast Neoplasms/pathologyMESH
Cell Proliferation/drug effectsMESH
Estrogen Receptor Modulators/chemical synthesisMESH
Estrogen Receptor alpha/metabolismMESH
Estrogen Receptor beta/metabolismMESH
Furans/chemical synthesisMESH
HumansMESH
LigandsMESH
Models, BiologicalMESH
Models, MolecularMESH
Protein BindingMESH
Tumor Cells, CulturedMESH
Keywords:Non-steroidal estrogen; Antiestrogen; Hormone-dependent breast cancer; Diphenylfuran; Estrogen receptor β
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:01 Dec 2008 14:34
Last Modified:05 Aug 2009 13:48
Item ID:4786
Owner Only: item control page
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