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Aroyl hydrazones of 2-phenylindole-3-carbaldehydes as novel antimitotic agents

Vogel, Susanne and Kaufmann, Doris and Pojarová, Michaela and Müller, Christine and Pfaller, Tobias and Kühne, Sybille and Bednarski, Patrick J and Angerer, Erwin von (2008) Aroyl hydrazones of 2-phenylindole-3-carbaldehydes as novel antimitotic agents. Bioorganic & Medicinal Chemistry 16 (12), pp. 6436-6447.

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Abstract

Cell cycle arrest of malignant cells is an important option for cancer treatment. In this study, we modified the structure of antimitotic 2-phenylindole-3-carbaldehydes by condensation with hydrazides of various benzoic and pyridine carboxylic acids. The resulting hydrazones inhibited the growth of MDA-MB 231 and MCF-7 breast cancer cells with IC(50) values of 20-30 nM for the most potent ...

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Item Type:Article
Date:2008
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
18513974PubMed ID
10.1016/j.bmc.2008.04.071DOI
Classification:
NotationType
Antimitotic Agents/chemical synthesisMESH
Benzoic Acids/chemistryMESH
Caspase 3/metabolismMESH
Cell Cycle/drug effectsMESH
Cell Line, TumorMESH
Cell Proliferation/drug effectsMESH
HumansMESH
Hydrazones/chemical synthesisMESH
Indoles/chemistryMESH
Pyridines/chemistryMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:03 Dec 2008 15:32
Last Modified:05 Aug 2009 13:48
Item ID:4787
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