Vogel, Susanne and Kaufmann, Doris and Pojarová, Michaela and Müller, Christine and Pfaller, Tobias and Kühne, Sybille and Bednarski, Patrick J and Angerer, Erwin von (2008) Aroyl hydrazones of 2-phenylindole-3-carbaldehydes as novel antimitotic agents. Bioorganic & Medicinal Chemistry 16 (12), pp. 6436-6447.
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Cell cycle arrest of malignant cells is an important option for cancer treatment. In this study, we modified the structure of antimitotic 2-phenylindole-3-carbaldehydes by condensation with hydrazides of various benzoic and pyridine carboxylic acids. The resulting hydrazones inhibited the growth of MDA-MB 231 and MCF-7 breast cancer cells with IC(50) values of 20-30 nM for the most potent ...
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|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)|
|Subjects:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||03 Dec 2008 15:32|
|Last Modified:||05 Aug 2009 13:48|