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[1,2-Bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II), a new compound for the therapy of ovarian cancer. III. Detailed evaluation of the antitumor activity of the enantiomeric complexes on the human NIH:OVCAR-3 ovarian cancer cell line

Bernhardt, Günther and Gust, Ronald and Reile, Herta and vom Orde, Hans Dieter and Müller, Richard and Keller, Christoph and Spruß, Thilo and Schönenberger, Helmut and Burgemeister, Thomas and Mannschreck, Albrecht and Range, Klaus Jürgen and Klement, Ulrich (1992) [1,2-Bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II), a new compound for the therapy of ovarian cancer. III. Detailed evaluation of the antitumor activity of the enantiomeric complexes on the human NIH:OVCAR-3 ovarian cancer cell line. Journal of cancer research and clinical oncology 118 (3), pp. 209-215.

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Abstract

The stereoisomeric [1,2-bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes were thoroughly tested on the cisplatin-resistant human NIH:OVCAR-3 ovarian cancer cell line. The racemate and its enantiomers produced cytocidal effects at a concentration of 2.5 microM (incubation time 256 h). The meso form, however, was merely cytostatically active. Differences between the enantiomers ...

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Item Type:Article
Date:1992
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Retired Professors > Prof.Dr. Mannschreck
Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
1548286PubMed ID
Classification:
NotationType
Antineoplastic Agents/pharmacologyMESH
Buthionine SulfoximineMESH
Cell LineMESH
Cisplatin/pharmacologyMESH
FemaleMESH
Glutathione/metabolismMESH
HumansMESH
Methionine Sulfoximine/analogs & derivativesMESH
Organoplatinum Compounds/pharmacologyMESH
Ovarian Neoplasms/drug therapyMESH
StereoisomerismMESH
Structure-Activity RelationshipMESH
Tumor Cells, Cultured/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Jan 2009 13:33
Last Modified:13 Mar 2014 18:32
Item ID:4813
Owner Only: item control page

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