Startseite UB

[1,2-Bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II), a new compound for the therapy of ovarian cancer. II. Synthesis and preliminary testing of the enantiomeric complexes

Bernhardt, Günther and Gust, Ronald and Reile, Herta and vom Orde, Hans Dieter and Müller, Richard and Keller, Christoph and Spruß, Thilo and Schönenberger, Helmut and Burgemeister, Thomas and Mannschreck, Albrecht and Range, Klaus-Jürgen and Klement, Ulrich (1992) [1,2-Bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II), a new compound for the therapy of ovarian cancer. II. Synthesis and preliminary testing of the enantiomeric complexes. Journal of cancer research and clinical oncology 118 (3), pp. 201-208.

[img]
Preview
PDF
Download (1MB)

at PubMed


Abstract

The enantiomeric [1,2-bis(2-hydroxyphenyl)-ethylenediamine]dichloroplatinum(II) complexes were synthesized and their configuration assessed. A preliminary test in the cisplatin-resistant human NIH:OVCAR-3 ovarian cancer cell line, which was previously characterized by its sensitivity against several therapeutically used drugs, showed that both enantiomers produce cytocidal effects in a ...

plus


Export bibliographical data

Item Type:Article
Date:1992
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institut für Organische Chemie
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
1548285PubMed ID
Classification:
NotationType
Adenocarcinoma/drug therapyMESH
Antineoplastic Agents/chemical synthesisMESH
Chromosome AberrationsMESH
FemaleMESH
HumansMESH
Molecular ConformationMESH
Organoplatinum Compounds/chemical synthesisMESH
Ovarian Neoplasms/drug therapyMESH
StereoisomerismMESH
Tumor Cells, Cultured/drug effectsMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Jan 2009 13:44
Last Modified:13 Mar 2014 18:32
Item ID:4814
Owner Only: item control page
  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact