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[meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] sulfatoplatinum(II)--pharmacokinetic studies

Bernhardt, Günther and Koch, Marion and Spruss, Thilo and Gust, Ronald and Krauser, Rudolf and Schlemmer, Richard and Hollstein, Michael and Lux, Franz and Schönenberger, Helmut (1999) [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] sulfatoplatinum(II)--pharmacokinetic studies. Archiv der Pharmazie 332 (6), pp. 195-200.

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Abstract

The maximally attainable level of the non-plasma protein bound fraction of a single 10.0 mumol/kg i.p. dose of [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] sulfatoplatinum(II), a drug active on the murine, hormone-sensitive MXT-M-3.2 breast cancer, lies markedly below the concentration causing a significant cytotoxic effect on a cell line derived from this tumor. This result ...

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Item Type:Article
Date:1999
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:SFB 234
Identification Number:
ValueType
10399488PubMed ID
10.1002/(SICI)1521-4184(19996)332:6<195::AID-ARDP195>3.0.CO;2-HDOI
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/pharmacokineticsMESH
Blood Proteins/metabolismMESH
Cisplatin/pharmacokineticsMESH
DNA/metabolismMESH
HumansMESH
MaleMESH
MiceMESH
Organoplatinum Compounds/pharmacokineticsMESH
Protein BindingMESH
Structure-Activity RelationshipMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Owner: Prof. Armin Buschauer
Deposited On:12 Dec 2008 17:25
Last Modified:19 Aug 2010 11:25
Item ID:4817
Owner Only: item control page
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