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Soluble tetraarylporphyrin-platinum conjugates as cytotoxic and phototoxic antitumor agents

Lottner, Christian and Bart, Karl-Christian and Bernhardt, Günther and Brunner, Henri (2002) Soluble tetraarylporphyrin-platinum conjugates as cytotoxic and phototoxic antitumor agents. Journal of medicinal chemistry 45 (10), pp. 2079-2089.

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A series of asymmetric tetraarylporphyrins was synthesized from pyrrole, para-substituted oligo- or poly(ethylene glycol) monomethyl ether benzaldehyde and from 4-hydroxybenzaldehyde etherified with diethyl bromomalonate according to the Lindsey method. After hydrolysis of the tetraarylporphyrin esters, the resulting carboxylic acid groups were used to bind platinum fragments. In comparison to ...


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Item Type:Article
Institutions:Chemistry and Pharmacy > Institut für Anorganische Chemie
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
11985475PubMed ID
Antineoplastic Agents/chemical synthesisMESH
Chelating Agents/chemical synthesisMESH
Drug Screening Assays, AntitumorMESH
Organoplatinum Compounds/chemical synthesisMESH
Photosensitizing Agents/chemical synthesisMESH
Porphyrins/chemical synthesisMESH
Structure-Activity RelationshipMESH
Tumor Cells, CulturedMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited On:12 Dec 2008 17:57
Last Modified:05 Aug 2009 13:48
Item ID:4825
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