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Hematoporphyrin-derived soluble porphyrin-platinum conjugates with combined cytotoxic and phototoxic antitumor activity

Lottner, Christian and Bart, Karl-Christian and Bernhardt, Günther and Brunner, Henri (2002) Hematoporphyrin-derived soluble porphyrin-platinum conjugates with combined cytotoxic and phototoxic antitumor activity. Journal of medicinal chemistry 45 (10), pp. 2064-2078.

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Abstract

To combine the cytotoxic activity of cisplatin and the phototoxicicity of hematoporphyrin derivatives in the same molecule, hematoporphyrin was derivatized at the two secondary alcohol positions by etherification with oligo- and poly(ethylene glycol) units. The two carboxylic acid groups of the propionate side chains were used to bind platinum fragments. The antiproliferative activity of 35 ...

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Item Type:Article
Date:2002
Institutions:Chemistry and Pharmacy > Institut für Anorganische Chemie
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
11985474PubMed ID
Classification:
NotationType
AgedMESH
Antineoplastic Agents/chemical synthesisMESH
Chelating Agents/chemical synthesisMESH
Drug Screening Assays, AntitumorMESH
FemaleMESH
Hematoporphyrins/chemical synthesisMESH
HumansMESH
LigandsMESH
LightMESH
MaleMESH
Middle AgedMESH
Organoplatinum Compounds/chemical synthesisMESH
Photosensitizing Agents/chemical synthesisMESH
Structure-Activity RelationshipMESH
Tumor Cells, CulturedMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:12 Dec 2008 17:15
Last Modified:05 Aug 2009 13:48
Item ID:4826
Owner Only: item control page
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