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Distribution and subcellular localization of a water-soluble hematoporphyrin-platinum(II) complex in human bladder cancer cells

Lottner, Christian and Knuechel, Ruth and Bernhardt, Günther and Brunner, Henri (2004) Distribution and subcellular localization of a water-soluble hematoporphyrin-platinum(II) complex in human bladder cancer cells. Cancer letters 215 (2), pp. 167-177.

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Abstract

The water-soluble porphyrin-platinum complex diammine[7,12-bis[1-(polyethyleneglycol-750-monomethylether-1-yl)ethyl]-3,8,13,17-tetramethylporphyrin-2,18-dipropionato]platinum(II) (PEG-HPPt) was studied with respect to cellular accumulation, subcellular localization, behavior in 3D-cell aggregates and degree of DNA platination on the low-differentiated J82 cells, a model of invasive bladder ...

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Item Type:Article
Date:2004
Institutions:Chemistry and Pharmacy > Institut für Anorganische Chemie
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
15488635PubMed ID
10.1016/j.canlet.2004.06.035DOI
Classification:
NotationType
Antineoplastic Agents/metabolismMESH
Cell LineMESH
Cell Line, TumorMESH
DNA, Neoplasm/metabolismMESH
Drug Screening Assays, AntitumorMESH
Hematoporphyrins/metabolismMESH
HumansMESH
Organoplatinum Compounds/chemistryMESH
Photosensitizing Agents/metabolismMESH
Platinum/metabolismMESH
Porphyrins/chemistryMESH
Spheroids, CellularMESH
Tissue DistributionMESH
Urinary Bladder/metabolismMESH
Urinary Bladder Neoplasms/drug therapyMESH
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:14 Jan 2009 12:19
Last Modified:05 Aug 2009 13:48
Item ID:4827
Owner Only: item control page
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